Process
- Take a diploid cell line (probably ESC or iPSC or PGCLC)
- Induce meiosis and form many haploid cell lines
- Genotype the haploid lines and select the best ones.
- Fuse two haploid cells to re-generate a diploid cell line.
- Repeat as desired. At the end, either differentiate the cells into oocytes or perform nuclear transfer into a donor oocyte.